In 5-Fluorouracil (5-FU)-resistantcolon cancer cells ectopic expression of miR-34a inhibited cell growth and attenuated the resistance to 5-FU through downregulation of SIRT1 and E2F3, inhibition of LDHA and of c-Kit, thus reducing stem cell factor (SCF)-induced migration/invasion (Akao et al., 2011). This evidence concerns the gene KITLG and cancer.