Ephrin type B receptor 2 (EPHB2) in small EVs derived from head and neck squamous cell carcinoma (HNSCC) activated ephrin-B reverse signaling and induced STAT3 phosphorylation in ECs, which promoted angiogenesis both in vitro and in vivo (Sato et al., 2019). The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.