Additionally, other angiogenic proteins have been found in many cancer cell-secreted EVs, such as yes-associated protein (YAP) (Wang et al., 2019b), angiopoietin 2 (ANGPT2) (Xie et al., 2020a), profilin 2 (PFN2) (Cao et al., 2020), Dll4 (Sheldon et al., 2010), ANG, IL-6, IL-8, tissue inhibitor of metalloproteinases-1 (TIMP-1), TIMP-2, activating transcription factor 2 (ATF2), metastasis associated 1 (MTA1), and Rho associated coiled-coil containing protein kinase 1/2 (ROCK1/2) (Skog et al., 2008; Chan et al., 2015; Yi et al., 2015; Ikeda et al., 2021). The gene discussed is TIMP1; the disease is cancer.