For example, lung cancer cell-secreted exosomal miR-210 activated the janus kinase 2 (JAK2)/STAT3 pathway by targeting ten-eleven translocation 2 (TET2) in fibroblasts and thus initiated the acquisition of the proangiogenic phenotype in CAFs, as indicated by the upregulation of VEGFA, MMP9, and FGF2 (Fan et al., 2020). Here, JAK2 is linked to lung carcinoma.