Ephrin type B receptor 2 (EPHB2) in small EVs derived from head and neck squamous cell carcinoma (HNSCC) activated ephrin-B reverse signaling and induced STAT3 phosphorylation in ECs, which promoted angiogenesis both in vitro and in vivo (Sato et al., 2019). Here, EPHB2 is linked to head and neck squamous cell carcinoma.