Uncombable hair syndrome is caused by the lack of crosslinking of intermediate filaments in the IRS (Tarcsa et al., 1997) and CCCA patients display reduced levels of both trichohyalin and S100A3, suggesting that reduced PADI3-mediated citrullination affects both target function and stability in the human hair shaft. Here, TCHH is linked to central centrifugal cicatricial alopecia.