Human PADI3 mutations are linked to uncombable hair syndrome, manifesting as frizzy and fair hair resistant to combing flat (Basmanav et al., 2016), and Central centrifugal cicatricial alopecia (CCCA), a type of scarring alopecia found predominantly in women of African ancestry (Malki et al., 2019). Here, PADI3 is linked to central centrifugal cicatricial alopecia.