In COAD and READ patients, we noticed that galactosyltransferases (B4GALT7, B3GALT6), glucuronyltransferase (B3GAT3), chondroitin synthase (CHSY3, CHSY1, CHPF2), and polymerizing enzyme (CHPF) were significantly increased compared to the normal adjacent tissues, while xylosyltransferase (XYLT1) and ofCS modification enzymes (CHST7, CHST15, UST) were both decreased. The gene discussed is CHPF2; the disease is reading.