In COAD and READ patients, we noticed that galactosyltransferases (B4GALT7, B3GALT6), glucuronyltransferase (B3GAT3), chondroitin synthase (CHSY3, CHSY1, CHPF2), and polymerizing enzyme (CHPF) were significantly increased compared to the normal adjacent tissues, while xylosyltransferase (XYLT1) and ofCS modification enzymes (CHST7, CHST15, UST) were both decreased. The gene discussed is UST; the disease is reading.