In COAD and READ patients, we noticed that galactosyltransferases (B4GALT7, B3GALT6), glucuronyltransferase (B3GAT3), chondroitin synthase (CHSY3, CHSY1, CHPF2), and polymerizing enzyme (CHPF) were significantly increased compared to the normal adjacent tissues, while xylosyltransferase (XYLT1) and ofCS modification enzymes (CHST7, CHST15, UST) were both decreased. Here, B4GALT7 is linked to colon adenocarcinoma.