Networks including MAPK, PI3K/Akt, JAK/STAT, NF-κB, TCR, and TLR downstream signalling were activated in malignant T-cells, facilitating ECM remodelling and tumour progression (Bastidas et al., 2018; Seto et al., 2018; Kamijo et al., 2018; Perez et al., 2020; Rendon-Serna et al., 2021). This evidence concerns the gene AKT1 and neoplasm.