Besides inducing HF via facilitating hyperactive proinflammatory responses, ADAM17 has been implicated along with HB-EGF and betacellulin (BTC), and angiotensin-converting enzyme 2(ACE2) in causing congenital heart diseases and hypertensive-induced HF, respectively (Jackson et al., 2003; de Queiroz et al., 2015; Xu et al., 2017; Mukerjee et al., 2019). The gene discussed is HBEGF; the disease is hydrops fetalis.