ADAM17 and cardiovascular disorder: Several studies have shown that myocardial ADAM17, TNFα, and sIL-6R expressions in both mRNA and protein levels are higher in patients with cardiovascular diseases and complications, although ADAM17’s expression is downregulated in a normal state (Satoh et al., 1999; Damås et al., 2000; Satoh et al., 2000; Satoh et al., 2004; Anderson et al., 2013).