CHEK2 and colonic neoplasm: Its role in DDR has been well studied; however, in human colon cancer cells, it has been reported that in the absence of damage, BRCA1 is phosphorylated by CHK2 at Serine 988 at centrosomes; this phosphorylation is important for the PP6C-SAPS3 phosphatase complex to be recruited to kinetochores and also to interact with BRCA1, preventing, on the one hand, the binding of AURORA A to BRCA1 and on the other hand, inhibiting the activity of AURORA A, favoring a proper assembly of the mitotic spindle (Figure 2) promoting adequate chromosome segregation.