In addition, using human colon cancer cells (HCT116) and osteosarcoma cells (U2OS), it was reported that CHK2 phosphorylated at Threonine 68 colocalized with centrosomes in mitotic cells (from late prophase until cytokinesis) and that this presence was PLK1-dependent. Here, CHEK2 is linked to malignant colon neoplasm.