BFT has three isotypes coded by the bft gene (bft-1, bft-2, and bft-3), among which bft-2 is the most common and most pathological isotype found in patients with CRC because of its enhanced mucosal adherence ability (Boleij et al., 2015; Jasemi et al., 2020). The gene discussed is PITX1; the disease is colorectal carcinoma.