BRAF and colorectal carcinoma: a) microsatellite instability (P=0.038)b) fewer BRAF V600 mutations (p<0.0001)As compared to late-onset CRC, EOCRC had higher frequency of CMS1 (22-23% vs 11%) and lower frequencies of CMS2 (43% vs 50%) and CMS4 (20-22% vs 27%).