Phosphorylation at S37 promotes the translocation of PKM2 to the nucleus, where PKM2 acts as a coactivator of transcription of several genes, including signal transducer and activator of transcription 5 (STAT5), to facilitate the expression of genes encoding cyclin D1, c-Myc, GLUT1, lactate dehydrogenase A (LDHA), and PKM2, all of which are essential for tumor cell metabolic reprogramming and proliferation (47–49). The gene discussed is PKM; the disease is neoplasm.