To conclude the application of CSF protein in miscellaneous conditions, CSF protein evaluation plays an important role in more current events such as the coronavirus disease 2019 (COVID-19). In the study by Tandon et al., CSF immunoglobulin M (IgM) and a combination of severe acute respiratory syndrome coronavirus 2 serum and CSF reverse transcriptase-polymerase chain reaction (CSF RT-PCR) testing were explored in patients with COVID-19 who had neurological symptoms. CSF RT-PCR, CSF (IgM) tests, and CNS-targeting antibodies can be used together to guide diagnosis, treatment, and outcomes. This evidence concerns the gene CD40LG and COVID-19.