In addition, a previous meta-analysis (Lu et al., 2014) has shown that male dermatomyositis patients older than 45-year-old with dysphagia, cutaneous necrosis, cutaneous vasculitis, rapid onset of myositis (<4 weeks), elevated creatine kinase (CK), elevated erythrocyte sedimentation rate (ESR), and elevated C-reactive protein (CRP) were more likely to develop malignancy, while interstitial lung disease (ILD), arthritis, Raynaud syndrome and the presence of anti-Jo-1 decreased that risk. This evidence concerns the gene CRP and arthritic joint disease.