Several researches found that PTEN mutation or down-expression had extensive influences on tumor microenvironment and PI3K signaling pathways, thus leading to tumor progression and poor prognosis in PC (Vidotto et al., 2020; Jamaspishvili et al., 2018; Garcia et al., 2014; Vidotto et al., 2019; Toso et al., 2014). The gene discussed is PTEN; the disease is neoplasm.