TF and adrenal cortex carcinoma: GSEA results showed that four hallmarks including G2M_CHECKPOINT (P = 0.021), E2F_TARGETS (P = 0.023), SPERMATOGENESIS (P = 0.046), and MITOTIC_SPINDLE (P = 0.048) were significantly enriched in high-risk patients, suggesting a mechanistic basis of the prognostic role of the 13-TF signature in ACC (Fig. 7).