We analyzed the gene expression profiles of ACC patients deposited in GEO and TCGA databases and constructed a prognostic signature of 13 TFs, including CREB3L3, NR0B1, CENPA, FOXM1, E2F2, MYBL2, HOXC11, ZIC2, ZNF282, DNMT1, TCF3, ELK4, and KLF6. The gene discussed is E2F2; the disease is adrenal cortex carcinoma.