Studies have shown that TGF-β/TGFBRs/Smads signaling is inhibited in osteoporosis and osteonecrosis of the femoral head induced by glucocorticoids (Li et al., 2017; Tao et al., 2017; Xie, Hu & Shi, 2018); however, the underlying mechanism remains unclear. This evidence concerns the gene TGFB1 and osteonecrosis.