Of note, FUT8-mediated core fucosylation is essential for TGF-β binding to TGFBRs (Schachter, 2005; Van Staa, Leufkens & Cooper, 2002), and TGF-β/TGFBRs/Smads signaling is inhibited in glucocorticoid-induced osteoporosis and osteonecrosis (Li et al., 2017; Tao et al., 2017; Xie, Hu & Shi, 2018). This evidence concerns the gene FUT8 and osteonecrosis.