HR and breast carcinoma: The OPTIMA trial, performed in 35 UK hospitals, evaluated the outcomes of 3 out of 4 genomic tests (the Oncotype DX test, MammaPrint and Prosigna) on patients over 40 years with HR+/HER2− early breast cancer and lymph nodes involvement (1 to 9) or, alternatively, a T >3 cm and N0.