Out of the fifteen pathways identified, a third appear to be conserved: (1) liver X receptor/retinoid X receptor (LXR/RXR activation), (2) neuroprotective role of THOP1 gene in Alzheimer’s disease, (3) glutamate receptor signaling, (4) nNOS signaling in skeletal muscle cells, and (5) calcium signaling pathways. Here, NOS1 is linked to early-onset autosomal dominant Alzheimer disease.