On the other hand, tumor suppressor role has been described for RASAL2 in a number of cancer types including luminal B breast cancers [22–24]; renal cancers [25]; bladder cancer [26, 27]; astrocytoma’s [28]; nasopharyngeal cancer [29]; pancreatic cancer [30]; ovarian cancer [31] and lung cancer [32]. This evidence concerns the gene RASAL2 and lung cancer.