After GPX4 knockdown, the expression of the inflammatory cytokines TNF-α, IFNγ, and IL-17 and the fibrotic cytokine TGF-β were upregulated to a greater extent in the livers of the AIH + AAV8-m-GPX4 group than those of the AIH + AAV8-EGFP group, while the anti-inflammatory cytokine IL-10 level was significantly downregulated (Figure 3(f); P < 0.05). The gene discussed is TGFB1; the disease is autoimmune hepatitis.