Meanwhile, the levels of the inflammatory cytokines TNF-α, IFNγ, and IL-17, and the fibrotic cytokine TGF-β, which play important roles in the pathology and progression of AIH, were increased, while the anti-inflammatory cytokine IL-10 level was decreased, further suggesting the presence of liver inflammation and fibrosis in the S100-induced AIH experimental mice. This evidence concerns the gene IFNG and autoimmune hepatitis.