The data showed that Ficus pandurata Hance had a good alleviated effect on IBD induced by DSS and a protective effect on secondary liver injury accompanied by IBD, mainly through inhibiting the inflammatory pathway LPS/TLR4/MyD88/NF-κB and enhancing the gut barrier through suppressing oxidative stress of the colon. This evidence concerns the gene NFKB1 and inflammatory bowel disease.