Uddin MN et al. identified numerous significantly upregulated genes, such as CTHRC1, NFE2L3, SULF1, SOX9, ENC1, and CCND1, and significantly downregulated genes, such as MYOT, ASPA, NEXMIF, ARHGEF37, BCL2, and PPARGC1A, in colon tumor stroma versus colon normal stroma [40]. This evidence concerns the gene ARHGEF37 and colonic neoplasm.