As an important transcription factor in the EMT process, Snail, which can move into the cell nucleus after phosphorylated at Ser246 and determine the relative expression of downstream N- and E-cadherin proteins [15, 16], is directly regulated by the upstream signaling pathway RAC-alpha serine/threonine-protein kinase (AKT)/Glycogen synthase kinase-3 beta (GSK-3β) during tumor progression [17, 18]. This evidence concerns the gene GSK3B and neoplasm.