EZH2 and breast cancer: For validated TFs, we further evaluated the expression correlations between them and CEMIP using the Breast Cancer Gene-Expression Miner based on 11,359 DNA microarrays and found that the expression levels of two up-regulated genes, TRIM28 and CTBP2, and two down-regulated genes, EGR1 and JUN, in BC were negatively associated with CEMIP, and one up-regulated gene EZH2 was positively correlated with CEMIP (Figures 4B–F; Supplementary Table S3).