Except for TP53 mutation, ARNT, ATF3, ESR1, TFAP2C, and ZNF217 alterations might also affect the expression of CEMIP. Meanwhile, we found three potential up-regulated genes (TRIM28, CTBP2, and EZH2) and two down-regulated genes (EGR1 and JUN) in BC compared with the normal breast tissues which might regulate CEMIP expression, especially EZH2, EGR1, and JUN, due to the fact that the correlations between their expression levels and CEMIP expression were consistent with the directions of change. The gene discussed is ESR1; the disease is breast cancer.