In the past decades, an increasing number of studies have revealed that high expression of CEMIP promotes numerous malignancy progresses and metastasis and predicts poor prognosis of cancer patients, including breast (Jami et al., 2014), colorectal (Fink et al., 2015), liver, gastric, pancreatic, lung (Li et al., 2020a), prostate, cholangitis (Zhai et al., 2020), ovarian (Shen et al., 2019), and papillary thyroid cancers (Liu et al., 2021a). Here, CEMIP is linked to cancer.