ERBB2 and cancer: For instance, the high level of lymphocytic infiltration may predict a better prognosis in patients with early-stage TNBC and HER2+ BC (Savas et al., 2016; Gao et al., 2020), whereas the infiltration of CAF and M2 macrophages may contribute to cancer progression (Ishii et al., 2016; Xia et al., 2020).