More convincingly, we discovered that high expression of CEMIP had a strong relationship with increased risk of death in BC patients according to both univariate and multivariate Cox regression analysis with hazard ratio (HR) = 1.17 and p-value = 0.028 of the latter, that is, holding the other covariates, that is., BC patient stage, age, ER/PR/HER2 status, TNM status, and TP53 mutation status, constant, a higher expression value of CEMIP predicted a poor survival of BC patients. Here, ESR1 is linked to breast cancer.