PTK2 and breast cancer: Moreover, we integrated all biological processes that CEMIP participated in and noticed that two down-regulated genes DDR2 and TGFBR2 in BC compared with normal breast tissues and four up-regulated genes, PTK2, RET, PRKD2, and CEMIP, were involved in the positive regulation of cell migration, positive regulation of cell motility, positive regulation of cellular component movement, and positive regulation of locomotion (Supplementary Tables S5, S6).