SIGLEC-1, which negatively regulates viral infection-triggered type I IFN production (67) in macrophages, was downregulated in our dataset - this further underscores a macrophage-mediated dysregulated IFN-response as a hallmark of severe disease (68), as previously observed in lung tissue of the same autopsy cohort (17). The gene discussed is SIGLEC1; the disease is viral infectious disease.