While the relative amount of T-cells was not decreased in COVID-19, a particular paucity of FOXP3-positive regulatory T-cell-equivalents (Treg) (median 0.75% compared to 12%, p<0.001) (Figures 2A and 3), Tbet-positive TH1-equivalents (median 2% compared to 12%, p=0.001) (Figures 2B and 3) and decreased amounts of LEF1-positive T-cells (median 15% compared to 25%, p=0.009) were observed (Figure 3). This evidence concerns the gene TBX21 and COVID-19.