Pathway enrichment analysis by means of GSEA, Gene Ontology and KEGG pathway sets revealed cell cycle related pathways, influenza vaccine mediated memory T-cell-response, MYC targets, mTORC1-signaling, epithelial-mesenchymal transition and fatty acid metabolism related pathways as the most significantly upregulated in COVID-19 versus controls. This evidence concerns the gene MYC and COVID-19.