VWF and Thrombocytopenia: Fibrin microthrombi in multiple capillary beds detected in post-mortem series (7, 12, 24), cytokine-induced complement activation (25), thrombocytopenia with hypersecretion of von Willebrand factor (vWF), angiopoietin 2 and coagulation factor VIII as well as IL-6 and fibrinogen (25–28) all point to a profound dysregulation of the innate immune response leading to thromboinflammation in severe COVID-19.