By stimulating Kupffer cells to activate the TLR4 signaling pathway, LPS induces the secretion of TNF-α, IL-1, IL-6, IL-12, and IL-18 in Kupffer cells (119, 120), thereby triggering hepatic steatosis, IR, and hepatocyte apoptosis, among others. The gene discussed is TNF; the disease is Hepatic steatosis.