Humans with loss-of-function mutation in leptin or leptin receptor have been found to be protected from hypertension despite obesity (Simonds et al., 2014), nevertheless, exogenous leptin administration does not increase blood pressure in leptin deficient states including congenital leptin deficiency and lipodystrophy (Brown et al., 2015). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.