Indeed, a relationship between hypertension and insulin resistance is further suggested by the finding that monotherapies with either enalapril (vasodilator ACE inhibitor) or rosiglitazone (insulin sensitizer), effectively reduce metabolic insulin resistance, plasma levels of ET-1 and blood pressure in spontaneously hypertensive rats (Potenza et al., 2006). The gene discussed is EDN1; the disease is Insulin resistance.