Salt intake has a close relationship with hypertension (Grillo et al., 2019) and may be a determinant of the pathogenetic link between salt sensitivity and insulin resistance, because it impairs insulin sensitivity in normotensive and hypertensive patients with salt sensitivity but not in those with salt resistance (Sharma et al., 1991; Zavaroni et al., 1995). This evidence concerns the gene INS and Hypertension.