The aromatic hydrocarbon receptor (AhR) is distributed in almost all tissues in various mammals and is expressed abundantly in the placenta, liver, and lungs, where it plays multiple roles in regulating the immune response, carcinogenesis, metabolic diseases, and neurophysiology (Xue et al., 2018; Girer et al., 2020; Vogel et al., 2020). Here, AHR is linked to metabolic disease.