BMAL1 is an important transcription factor in this feedback loop that may suppress the growth, proliferation, and proliferation of multiple cancer cells, including tongue squamous cancer cells, colorectal cancer cells, breast cancer cells, and ovarian cancer cells (Gréchez-Cassiau et al., 2008; Hanahan and Weinberg, 2011; Elshazley et al., 2012; Hsu et al., 2012). The gene discussed is BMAL1; the disease is breast cancer.