Peripheral nerve injury activated a characteristic set of signaling pathways in both sexes, including HMGB1 Signaling, TREM1 signaling, IL-6 Signaling, IL-17 Signaling, Integrin signaling, HIF1α Signaling, Oxytocin Signaling, and ILK Signaling. The gene discussed is HIF1A; the disease is peripheral nerve injury.