The top canonical pathways regulated by these networks include B Cell Development (P = 2.1e-4), IL-7 (P = 7.0e-4) and IL-17A (P = 3.4e-2) Signaling pathways, PI3K Signaling in B Lymphocytes (P = 2.3e-3), Role of JAK1/JAK3 in Cytokines signaling (P = 5.5e-4), Primary Immunodeficiency (P = 2.6e-6), and Sonic Hedgehog signaling (P = 1.5e-2). This evidence concerns the gene IL7 and inborn error of immunity.