These mediators might also contribute to inflammation and colon tumor development, as observed by the significant association of SNPs mapping in this region with colon tumors; the region in chromosome 8 at 54 Mb harbors the Vegf-C (vascular endothelial growth factor C) gene which is the main regulator of angiogenesis in the process of tumor growth and metastasis. Here, VEGFC is linked to colonic neoplasm.