Studies indicate that this gene is activated constitutively in malignant tumors and the action of some molecules with anti-tumor activity is attributed to the inactivation of this factor [29, 30]; a group of genes encoding alcohol dehydrogenases (Adh1, Adh5, Adh6a, Adh6b, Adh7) maps at 138 Mb. The gene discussed is AKR1A1; the disease is neoplasm.