EGF and colitis: This region harbors some candidate genes including Sgms2 (Sphingomyelin synthase 2S), which has a role in inflammation-mediated tumorigenesis, such as colon cancer originating from colitis [27]; Egf (epidermal growth factor) whose product is secreted by tumor cells of the colon and contributes to the M2 polarization of macrophages associated with the tumor [28]; NF-κB1 (nuclear factor-kappa B), that promotes cell proliferation, regulates immunological and inflammatory responses.