EGF and neoplasm: The neovascularization is also crucial for tumor invasion and metastasis, referring to many factors, such as hypoxia, hyperosmotic pressure and angiogenic factors such as VEGF, transforming growth factor β (TGF-β), cyclooxygenase-2 (COX-2), placenta growth factor (PGF), fibroblast growth factor (FGF) [54], epidermal growth factor (EGF), platelet-derived growth factor (PDGF), angiotensin (Ang), and chemokines [55–57].