Eisinger et al. demonstrated that targeting an immune-suppressive TAM subtype by specific antibodies against the scavenger receptor MARCO resulted in the phenotypic conversion of TAMs into proinflammatory TAMs that recruited and activated more NK cells to enhance the TNF-related apoptosis-inducing ligand (TRAIL) mediated effect of tumor cell killing [93]. This evidence concerns the gene TNFSF10 and neoplasm.