By contrast, thyroid stimulating hormone receptor (TSHR) and lysine demethylase 6B (KDM6B), which are known primary antigens in autoimmune diseases, including Graves' disease and Hashimoto's disease [13] and systemic sclerosis (SS also termed scleroderma) [14] were highly expressed in asymptomatic males. This evidence concerns the gene KDM6B and Graves disease.