Our findings revealed a broad anti-viral immune response detected in previously COVID-19 infected individuals that included reactivity to proteins with molecular homology with SARS-CoV-2 including: MOV10, a protein interaction partner of SARS-CoV-2; adenylate kinase 4 (AK4), a Y14-protein homologue of SARS-CoV-2); and, La ribonucleoprotein domain family member 1 (LARP1), a N protein interaction partner of SARS-CoV-2. Here, MOV10 is linked to COVID-19.