NUMA1 and mixed connective tissue disease: The most abundant AABs in males were preferentially enriched in classical nuclear AABs such as small nuclear ribonucleoprotein polypeptide C (SNRPC) a target of autoreactive B cells and T cells in several rheumatic diseases including SLE, mixed connective tissue disease (MCTD) [15], inflammatory myositis, and SS [16]; nuclear mitotic apparatus protein 1 (NUMA1), antibody associated with SLE, SS, and RA [17]; and autoantibodies recognizing dihydrolipoamide succinyltransferase (DLST) found in primary biliary cirrhosis [18].