Several ovarian cancer gene sets, including BUB1, CCNA2, CCNB2, CDC2, CDC20, CENPE, CENPF, ESPL1, HMMR, and HPN, as well as gene sets of the cell proliferation marker MKi76 and proliferating cell nuclear antigen (PCNA), were significantly upregulated in BRCA1mut-FTE organoids compared with those in controls (Figure 4D; Figure S5; Table S1; Adib et al., 2004; Buttermore et al., 2017; Cahill et al., 1998; Feng et al., 2019; Li et al., 2018; Sun et al., 2017). The gene discussed is ESPL1; the disease is ovarian carcinoma.