TP53 and cancer: Primary cells from the control transplants did not survive (data not shown); however, primary cells from BRCA1mut tumor lesions have the ability to grow in a multilayer (Figure 6D) and exhibited clear production of FTE markers and cancer markers, including CDH1, PAX8, and Ki67, and increases in the frequency of double-stranded DNA break, shown with γH2AX accumulation and heterogenous TP53 staining, which is compatible with a wild-type pattern of TP53 expression (Figure 6E).