RNA-seq and subsequent GSEA analysis showed that ovarian-cancer-related modules that promote cell migration, invasion, and malignant transformation including TPT1, NPM1, RAN, and predictive markers such as CK2β and PSME1 were significantly upregulated in BRCA1mut-FTE organoids, further suggesting neoplastic progression in vitro (Figure 5D; Figure S6D; Table S3; Chen et al., 2015; Liu et al., 2016; Londero et al., 2014; Ma et al., 2017; Wong et al., 2001; Zaoui et al., 2019). The gene discussed is RAN; the disease is ovarian cancer.