Additionally, clustering may contribute to the CaMKII accumulation at excitatory spine synapses during both LTP and ischemia (Hudmon et al., 2005), although CaMKII binding to GluN2B is at least a co-requirement for both (Bayer et al., 2001; Buonarati et al., 2020; Halt et al., 2012). Here, GRIN2B is linked to ischemia.