For the RSF before imputation see (Fig 5), the top 20 genes/ covariates that are most important and strongly associated with the CRC obtained using the log-rank split-rule are age, SLC28A3, stages, TNFSF9, EGLN3, molecular subtype, CTSV, ANKRD27, POLR3B, CTSA, SYTL1, MYRF, RPS27L, L3MBTL1, PIPOX, ADPRM, SLC6A4, LDLRAD3, MSRA, and SCAND1. This evidence concerns the gene CTSV and colorectal carcinoma.