For the RSF before imputation see (Fig 5), the top 20 genes/ covariates that are most important and strongly associated with the CRC obtained using the log-rank split-rule are age, SLC28A3, stages, TNFSF9, EGLN3, molecular subtype, CTSV, ANKRD27, POLR3B, CTSA, SYTL1, MYRF, RPS27L, L3MBTL1, PIPOX, ADPRM, SLC6A4, LDLRAD3, MSRA, and SCAND1. The gene discussed is POLR3B; the disease is colorectal carcinoma.