Detecting the expression of 19 genes in 7 CRC cell lines and CCD841CON revealed that HPDL, LGR5, ASCL2, KCNE3, HNF4G, KRT8, KRT18, SLC12A2 and FERMT1 were significantly overexpressed in CRC cell lines (Figure 3B). The gene discussed is KRT8; the disease is colorectal carcinoma.