The ATG16L1 rs2241880 G-allele is thought to impair autophagy, which in itself is required for reducing cellular ER-stress.39–41 As such, ATG16L1 rs2241880 is associated with enhanced accumulation of unfolded proteins and ER stress markers in gastrointestinal disease. The gene discussed is ATG16L1; the disease is gastrointestinal disease.