HSPA5 and gastric cancer: Alternative ER stress alleviation comes from the unfolded protein response (UPR), aimed at temporarily blocking protein synthesis,17 and ER-stress markers and the UPR are indeed known to be induced in GC.18 The most important ER-stress biomarker, the unfolded protein chaperone GRP78, was associated with poor patient survival in a GC cohort comprising 328 patients.19