In contrast, infants with L293R had greater abundance of genes in both the “IBD-associated genes” cluster including RORA/NR1F1, NR1F3, IL23R, and PLCB1 (Figure 7a), and “B cell-associated genes” cluster including IGHV/VDJ, LILRB3, IgA, Cdc22, and MALT1 (Figure 7c). The gene discussed is PLCB1; the disease is inflammatory bowel disease.