Prion protein gene (PRNP) mutations cause distinct clinical symptoms in patients with genetic forms, including Gerstmann-Sträussler-Scheinker disease (GSS), fatal familial insomnia (FFI), and genetic Creutzfeldt Jakob disease (g-CJD) [1]. This evidence concerns the gene PRNP and Gerstmann-Straussler-Scheinker syndrome.