MAPT and prion disease: The clinical features of V180I CJD are as follows: (1) older onset age; (2) slower disease progression compared with sporadic CJD; (3) a relatively low occurrence rate of symptoms such as myoclonus, cerebellar symptoms, and visual disturbances; (4) a lower positive rate of brain-specific proteins, such as NSE, total tau protein, and 14-3-3 protein, in CSF; (5) a lack of PSD on EEG throughout the disease course; and (6) no family history of prion disease [3].