MAPT and supranuclear palsy, progressive, 1: While many RNA binding proteins (RBPs) were discovered to be linked to Tau exon 10 splicing regulation [22–31], to date it remains uncertain how dysregulation of these known RBPs might contribute to the selective accumulation of 4 R-Tau or 3 R-Tau in PSP and other sporadic splicing-related tauopathies.