Besides FTDP-17, in many other tauopathies, such as progressive supranuclear palsy (PSP) and Pick’ disease (PiD), post-mortem brain autopsies reveal that Tau aggregates are also preferentially enriched with 4 R-Tau and 3 R-Tau isoforms, respectively [20]. This evidence concerns the gene MAPT and frontotemporal dementia.