Since a previous study had confirmed the interaction between CLDN2, ZO1 and ZONAB, which was involved in human lung adenocarcinoma cell proliferation,22 we wondered if CLDN2 indirectly modulates the expression of NDRG1 by similarly interacting with ZO1/ZONAB in colorectal cancer cells. The gene discussed is TJP1; the disease is lung adenocarcinoma.