CLDN2 and colorectal cancer: To uncover the underlying molecular mechanism of how CLDN2 facilitate colorectal cancer progression, we performed RNA sequencing (RNA‐seq) on CRISPR‐mediated CLDN2 knockout cells (HT29sgCLDN2 and HT29V2) and CLDN2‐expressing cells (HCT116CLDN2‐GFP and HCT116GFP).