Twenty-four genes overlappedbetween the two cohorts: APC, ATM, BRCA1, BRCA2, BRIP1, CDKN1B, CDKN2A, COL7A1,EPCAM, HNF1A, MLH1, MUTYH, PALB2, PMS2, PTCH1, PTPN11, RAD50, RECQL4, SDHB, SERPINA1,SMAD4, TP53, TSC1 and WRN, suggesting that these genescontribute to cancer susceptibility worldwide (see the Venn diagram in Figure 2). This evidence concerns the gene SMAD4 and cancer.