NM23 has been reported to suppress transforming growth factor-β1-induced EMT,[78] which maybe associated with the increased expression of E-cadherin.[77] EMT results in the weaken of adhesion and enhance of migration of tumor cells, which makes tumor cells entering the blood and generates circulating tumor cells, and the circulating tumor cells are able to predict metastatic relapse and are related to disease progression and worse clinical outcome.[79]. Here, CDH1 is linked to neoplasm.