CX3CR1 and Candidemia: Besides the aforementioned genetic variation in the CXCR1, CX3CR1, CD82, and TLR gene loci [145,321,324,346], additional population studies have revealed increased susceptibility to systemic candidiasis in patients with certain genetic variants in the TNF, IL10, IL12B, CCL8, CD58, TAGAP, LCE4A-C1orf68, PSMB8, SP110, and STAT1 genes; strikingly, the combinatorial presence of certain genetic variants has been reported to lead to up to ~20-fold increases in host susceptibility to candidemia [144,362–365].