SYK-deficient mice are susceptible to systemic candidiasis (and other fungal infections) and SYK-deficient neutrophils are unable to control several Candida species associated with defects in ROS production, cytokine production, neutrophil extracellular trap (NET) formation, phagocytosis, and neutrophil swarming [111,112]. Here, SYK is linked to fungal infectious disease.