TLR4 and candidiasis: Indeed, C. albicans strain-specific differential dependence on PRR recognition has also been documented for DECTIN-1 and TLR4, which recognizes C. albicans O-linked mannans [132,137–141]; in the setting of candidiasis in vivo, these differences underlie a wide variety of outcomes ranging from conferring survival benefit to promoting lethal immunopathology.