FGF2-Akt and BDNF-TrkB signaling pathways were reactivated by Rg1 in the hippocampus and prefrontal cortex to inhibit neuronal apoptosis and prevent cognitive deficits and experimental basis for the development and use of ginsenoside for anti-aging and age-related diseases [13]. The gene discussed is NTRK2; the disease is Cognitive impairment.