High PPP4C expression can improve tumor resistance to platinum by improving nuclear factor kappa B subunit 1 (NF-κB) expression [33], and inhibition of PPP4C leads to sustained phosphorylation and ubiquitination of γ-microtubule proteins, resulting in blocked microtubule nucleation, which enhances the anticancer effect of paclitaxel [34]. Here, NFKB1 is linked to neoplasm.