Puerarin significantly reduced the expression of the receptor for advanced glycation end products (RAGE), improved autophagy function via upregulation of its essential components of beclin, microtubule‐associated protein 1A/1B‐light‐chain 3 (LC3II), and autophagy related 5 (ATG5), increased the antioxidant activity of heme oxygenase (HO) and the anti‐aging molecule SIRT1 expression, alleviated endoplasmic reticulum (ER) stress, reduced hyperglycemia, and eventually improved renal function in diabetic rats.28, 29, 30. This evidence concerns the gene ATG5 and Hyperglycemia.