In the amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice, puerarin increased NrF‐2 and its downstream antioxidant molecule heme oxygenase 1 (HO‐1) and alleviated oxidative stress damage, blocked amyloid beta (aβ) deposition, and rescued cognitive decline.57 This evidence concerns the gene APP and Mental deterioration.