However, that meta-analysis did not consider variation in the RRs by age, PCa family history, ethnicity or PV location despite evidence of variation by these factors [1–8, 10–12, 14–17, 23, 28–33], and did not include two subsequent studies that reported prospective RR estimates for BRCA1/2 carriers: the IMPACT screening trial [20] and the EMBRACE study [23]. Here, BRCA1 is linked to posterior cortical atrophy.