The pooled random-effects RRs of aggressive PCa (any definition) were 1.98 (1.35–2.90; I2 = 0%) for BRCA1 carriers and 6.08 (3.44–10.8; I2 = 82%) for BRCA2 carriers (Supplementary Fig. S16). The gene discussed is BRCA2; the disease is posterior cortical atrophy.