Comparing log2 fold changes across all genes in sporadic ALS with the mutation-carrying pan ALS (meta-analysis) astrocytes revealed an overall negative correlation (R = −0.1, P < 2.2 × 1016), with only a single overlapping differentially expressed gene (NCKAP5) (Supplemental Fig. S5B). The gene discussed is NCKAP5; the disease is amyotrophic lateral sclerosis.