GSEA revealed a nonsignificant overall decrease in the expression of the glutamate uptake gene set in models of mouse ALS astrocytes (NES −0.8, P = 0.96), although we did note significant decreases in many individual glutamate transporter-related genes, including Slc1a3, Il1rap, Eps15, Tnr, Grin2c, Sptbn2, Septin11, Sptbn1, and Arhgap39 (Supplemental Fig. S8H). This evidence concerns the gene EPS15 and amyotrophic lateral sclerosis.