MOB3B and amyotrophic lateral sclerosis: Of note, in all four independent ALS mutant astrocyte data sets, gap junction protein beta 2 (GJB2) was significantly increased in expression, whereas LRRC3B (also known as LRP15) and MOB kinase activator 3B (MOB3B) were significantly decreased in expression—the latter of which itself shows ALS-associated loci (Li et al. 2021).