To identify common changes across astrocytes carrying diverse ALS mutations, we reanalyzed published RNAseq datasets from ALS hiPSC-derived astrocytes carrying C9orf72 (Birger et al. 2019), SOD1 (Tyzack et al. 2017), and FUS (Neyrinck et al. 2021) mutations (C9orf72 data set: two mutant and two control lines; SOD1: three mutants and four controls; FUS: six mutants and six controls). Here, SOD1 is linked to amyotrophic lateral sclerosis.