TLR3 and amyotrophic lateral sclerosis: Eight genes were significantly increased in expression in mouse ALS models but significantly decreased in both MCAO and SCI protective astrocytes (Atp6ap2, Ndufv3, Prkd1, Psenen, Slc25a20, Suclg1, Tlr3, Tspan3; ANOVA test P = 0.0005), and 14 genes were decreased in mouse ALS models but increased in both protective astrocyte data sets (including Adamts4, Ddx54, Dst, Myo5a, Nfasc, Pdgfa, Phldb1, Pus7, Synm; P = 0.12) (Supplemental Table S9).