HLA-DRB1 and Autoimmunity: This may be because HLA is involved in choroidal inflammation and the HLA-DRB1*04 group is more responsive to inflammation, because in previous article of autoimmunity area including rheumatoid arthritis, described that HLA-DRB1*04 group implicate those residues around the putative antigen binding site of the DR beta molecule in the pathogenesis.