Its low-density lipoprotein (LDL) receptor-binding region containing residues 136–150 is within this four-helix bundle and includes rich lysyl and arginyl residues; therefore, drug delivery may be mediated through the interactions of ApoE with the LDL receptor (LDLr) and LDLr-related protein 1 receptor (LRP1r) on cancer cells. The gene discussed is LDLR; the disease is cancer.